Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1352-7. doi: 10.1016/j.bmcl.2011.12.069. Epub 2011 Dec 21.

Abstract

The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10-17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2-4, 8, and 10-26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromine* / chemistry
  • Bromine* / pharmacology
  • Carbonic Anhydrase Inhibitors* / chemical synthesis
  • Carbonic Anhydrase Inhibitors* / chemistry
  • Carbonic Anhydrase Inhibitors* / pharmacology
  • Carbonic Anhydrases* / chemistry
  • Crystallography, X-Ray
  • Cyclohexanones* / chemical synthesis
  • Cyclohexanones* / chemistry
  • Cyclohexanones* / pharmacology
  • Enzyme Activation / drug effects
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Phenols* / chemical synthesis
  • Phenols* / chemistry
  • Phenols* / pharmacology

Substances

  • Carbonic Anhydrase Inhibitors
  • Cyclohexanones
  • Phenols
  • Carbonic Anhydrases
  • Bromine